Immune Desert CD8 Macrophage Bias

Archetype Feature Distributions
Tcells  Myeloid  Stromal  Treg   CD4 Tcells   CD8 Tcells Monocytes  Macrophages  cDC2 cDC1
Low Low High Low Low Very High Low Very High Variable Very Low

 


Potential Origin of this Archetype

Late Wound healing, CD8, Macrophage Axis, Susstained by CX3CR1 signalling

Archetype Tumor transcriptomic program

Cell Dvision (G1-S ; G2-M), Fibrosis, EMT

Archetype Chemokines Expressed

CCL26, CCL27, CCL28, CCR10, CXC3CL1, CX3CR1

Archetype Immune Transcriptomic Programs

PD1-PDL1, High Exhaustion, IFN,TNFa signalling


 

Table of Archetype flow Populations      Immune Archetype Gene Signature      Table of Archetype Feature Scores

 


Histology Abbreviations

PSC = Papillary  Serous Cystadenocarcinoma    SCC = Squamous Cell Carcinoma NOS     EA = Endometriod Adenocarcinoma  S = Sarcoma NOS

SampleGenderRaceEthnicityBMIAgeT StageN StageM StageGradeHistologyTumor typeExtraction Site
IPIGYN059.T1FemaleWhiteNon Hispanic or Latino42.67541cXG2: Moderately differentiated (intermediate grade)EAPrimaryovary
IPIGYN096.T1FemaleOtherHispanic or Latino42703aX1G3: Poorly differentiated (high grade)PSCPrimaryuterus
IPIGYN099.T1FemaleOtherNon Hispanic or Latino25551b0G1: Well differentiated (low grade)EAPrimary
IPIHNSC021.T1FemaleWhiteNot reported20.27424bX0G3: Poorly differentiated (high grade)SCCPrimaryparanasal sinus
IPIHNSC024.T1FemaleWhiteNon Hispanic or Latino25.2744aXG3: Poorly differentiated (high grade)OtherPrimarynasal cavity
IPIMELB003.T1Male
IPISRC015.T1MaleBlack or African AmericanNon Hispanic or Latino46402a11G3: Poorly differentiated (high grade)SMetastasisinguinal part of abdomen