Immune Desert Monocyte Bias

Archetype Feature Distributions
Tcells  Myeloid  Stromal  Treg   CD4 Tcells   CD8 Tcells Monocytes  Macrophages  cDC2 cDC1
Low Low Variable Variable Variable Variable Very High Very Low Low Low

 


Potential Origin of this Archetype

Early Wound healing, Tissue resident T cells, Supressive T reg, Neutrophils Axis,  Sustained by IL1 signalling

Archetype Tumor transcriptomic program

Cell Dvision (G1-S ; G2-M), Proteasome pathway, Autophagy

Archetype Chemokines Expressed

N/A

Archetype Immune Transcriptomic Programs

Tissue Resident T cells (Trem), IL1b, ARG1 signalling, Suppresive Tregs,  Neutrophils


 

Table of Archetype flow Populations      Immune Archetype Gene Signature      Table of Archetype Feature Scores

 


Histology Abbreviations

ADC = Adenocarcinoma NOS    PSC = Papillary  Serous Cystadenocarcinoma   PC = Papillary  Carcinoma  C = Carcinoma NOS  SCC = Squamous Cell Carcinoma NOS  CCC = Clear Cell Carcinoma NOS   EA = Endometriod Adenocarcinoma  NET = Neuroendocrine Tumor  TCC = Transitional Cell Carcinoma NOS, CHO = Cholangiocarcinoma

SampleGenderRaceEthnicityBMIAgeT StageN StageM StageGradeHistologyTumor typeExtraction Site
IPIBLAD013.T1MaleWhiteNot reported26604a0G3: Poorly differentiated (high grade)CPrimary
IPIBLAD024.T1FemaleAsianNon Hispanic or Latino28773aXG3: Poorly differentiated (high grade)CPrimaryUreter
IPICRC035.T1MaleWhiteNon Hispanic or Latino31.313931cG1: Well differentiated (low grade)ADCPrimaryrectum
IPICRC057.T1MaleOtherHispanic or Latino31.28644a20G1: Well differentiated (low grade)ADCPrimary
IPICRC064.T1FemaleWhiteNon Hispanic or Latino25.7574300G3: Poorly differentiated (high grade)ADCPrimarytransverse colon
IPICRC072.T1FemaleWhiteNon Hispanic or Latino34.26830G2: Moderately differentiated (intermediate grade)ADCPrimarycaecum
IPICRC074.T1FemaleOtherHispanic or Latino31.73430G2: Moderately differentiated (intermediate grade)ADCPrimarycaecum
IPICRC077.T1MaleAsianNon Hispanic or Latino31.946921G2: Moderately differentiated (intermediate grade)ADCPrimarytransverse colon
IPICRC080.T1FemaleWhiteNon Hispanic or Latino32.778930G2: Moderately differentiated (intermediate grade)ADCPrimarycaecum
IPIGYN011.T1FemaleOtherHispanic or Latino30.3363XG3: Poorly differentiated (high grade)EAPrimaryovary
IPIGYN011.T2FemaleOtherHispanic or Latino30.3363XG3: Poorly differentiated (high grade)EAPrimaryovary
IPIGYN018.T2FemaleWhiteNon Hispanic or Latino39.03613c1G3: Poorly differentiated (high grade)CPrimaryovary
IPIGYN109.T1FemaleWhiteNon Hispanic or Latino22.82573c1XG3: Poorly differentiated (high grade)PSCPrimarypelvic region element
IPIHEP001.T1FemaleWhiteNon Hispanic or Latino236610G2: Moderately differentiated (intermediate grade)CHOPrimarygall bladder
IPIHEP017.T1MaleWhiteNon Hispanic or Latino257040G3: Poorly differentiated (high grade)ADCPrimary
IPIHNSC061.T1MaleAsianNon Hispanic or Latino19.35674a20G2: Moderately differentiated (intermediate grade)SCCPrimarylarynx
IPIHNSC073.T1FemaleWhiteNot reported24.95694a30Not AvailableSCCLocalRecurrenceoral cavity
IPIKID060.T1MaleOtherHispanic or Latino20781bXG3: Poorly differentiated (high grade)CCCPrimaryright kidney
IPIKID106.T1MaleWhiteNon Hispanic or Latino21653a01G2: Moderately differentiated (intermediate grade)CCCPrimaryleft kidney
IPILUNG009.T1MaleWhiteNon Hispanic or Latino34732a0G3: Poorly differentiated (high grade)ADCPrimarylower lobe of left lung
IPILUNG051.T1FemaleWhiteNon Hispanic or Latino19591a0G2: Moderately differentiated (intermediate grade)ADCPrimarylower lobe of left lung
IPIMEL056.T1MaleWhiteNon Hispanic or Latino28414b31Not AvailableNevi & MelanomasMetastasisleft axillary sentinel lymph node
IPIMEL105.T2MaleWhiteNon Hispanic or Latino3069X3Not AvailableNevi & MelanomasMetastasisLeft axillary sentinel lymph node
IPIMEL208.T1FemaleWhiteNon Hispanic or Latino1459100Not AvailableOtherPrimarySpleen
IPIMEL221.T1FemaleWhiteNon Hispanic or Latino38734b00Not AvailableNevi & MelanomasPrimaryscalp
IPIMEL348.T1FemaleWhiteNon Hispanic or Latino2967X1b0G1: Well differentiated (low grade)Not AvailablePrimaryLeft groin extranodal
IPIMEL353.T1MaleWhiteNon Hispanic or Latino36694a21cNot AvailableNot AvailablePrimaryscalp
IPIPNET005.T1MaleWhiteNon Hispanic or Latino323321G1: Well differentiated (low grade)NETPrimaryPancreas
IPIPNET009.T1FemaleBlack or African AmericanNon Hispanic or Latino323920G1: Well differentiated (low grade)NETPrimaryPancreas
IPIPNET010.T1FemaleWhiteNon Hispanic or Latino226530G1: Well differentiated (low grade)NETPrimaryPancreas