Immune Rich CD4 Macrophage Bias

Archetype Feature Distributions
Tcells  Myeloid  Stromal  Treg   CD4 Tcells   CD8 Tcells Monocytes  Macrophages  cDC2 cDC1
Variable Variable Low High High Low Low Variable High Low

 


Potential Origin of this Archetype

Epithelial homestasis in the Stromal Treg axis sustained by IFN/CCR2 TGFb

Archetype Tumor transcriptomic program

ER Stress  (CH25H, ERN2)

Archetype Chemokines Expressed

CCL17, CCL18, CCR4, CCR8

Archetype Immune Transcriptomic Programs

TGFb signaling , enriched in DC3 anfd resting Tregs

 


 

Table of Archetype Flow Populations    Immune Archetype Gene Signature   Table of Archetype Feature Scores

 

Histology Abbreviations

ADC = Adenocarcinoma NOS    PC = Papillary  Carcinoma NOS   C = Carcinoma NOS    CCC = Clear Cell Adenocarcinoma NOS  

SampleGenderRaceEthnicityBMIAgeT StageN StageM StageGradeHistologyTumor typeExtraction Site
IPIBLAD026.T1MaleOtherNon Hispanic or Latino316110XG3: Poorly differentiated (high grade)Clear Cell Adenocarcinoma NOSPrimaryUreter
IPICRC087.T1FemaleWhiteNon Hispanic or Latino17.837030G2: Moderately differentiated (intermediate grade)ADCPrimaryascending colon
IPICRC088.T1MaleAsianNon Hispanic or Latino16.64834a21G2: Moderately differentiated (intermediate grade)ADCPrimaryascending colon
IPICRC090.T1MaleWhiteNon Hispanic or Latino25.93631bG2: Moderately differentiated (intermediate grade)ADCPrimaryrectum
IPIGYN013.T1FemaleAsianNon Hispanic or Latino19.665910G3: Poorly differentiated (high grade)CCCPrimaryovary
IPIKID108.T1MaleAsianNon Hispanic or Latino27543b0G3: Poorly differentiated (high grade)PCPrimaryright kidney
IPILUNG008.T1FemaleWhiteNon Hispanic or Latino20721a0G1: Well differentiated (low grade)ADCPrimaryupper lobe of right lung
IPILUNG013.T1MaleWhiteNon Hispanic or Latino22801b1G2: Moderately differentiated (intermediate grade)ADCPrimaryupper lobe of left lung
IPILUNG014.T1FemaleBlack or African AmericanNon Hispanic or Latino20811b1G3: Poorly differentiated (high grade)ADCPrimaryupper lobe of left lung
IPILUNG015.T1MaleWhiteNon Hispanic or Latino28831a0G2: Moderately differentiated (intermediate grade)ADCPrimary
IPILUNG030.T1FemaleOtherNon Hispanic or Latino39611b0G3: Poorly differentiated (high grade)ADCPrimary
IPILUNG041.T1FemaleAsianNon Hispanic or Latino28792a2G2: Moderately differentiated (intermediate grade)ADCPrimarylower lobe of right lung
IPILUNG054.T1FemaleWhiteNon Hispanic or Latino33761aXG2: Moderately differentiated (intermediate grade)ADCPrimaryupper lobe of right lung
IPILUNG058.T1MaleWhiteNon Hispanic or Latino30751bXG2: Moderately differentiated (intermediate grade)ADCPrimaryupper lobe of left lung
IPILUNG069.T1MaleWhiteNon Hispanic or Latino27631b2G3: Poorly differentiated (high grade)ADCPrimaryupper lobe of right lung
IPILUNG076.T1FemaleAsianNon Hispanic or Latino20592a0G2: Moderately differentiated (intermediate grade)ADCPrimaryupper lobe of right lung
IPILUNG080.T1MaleAsianNon Hispanic or Latino25692a1G3: Poorly differentiated (high grade)ADCPrimarylower lobe of right lung
IPIMEL252.T1MaleWhiteNon Hispanic or Latino18613b30Not AvailableNevi & MelanomasPrimaryright arm
IPIMEL253.T1MaleWhiteNon Hispanic or Latino30624bX1cNot AvailableNevi & MelanomasMetastasisretroperitoneal lymph node
IPIMEL255.T1MaleWhiteNon Hispanic or Latino36484b20Not AvailableNevi & MelanomasMetastasisLeft axilla, sentinel lymph node