Archetype Feature Distributions
| Tcells | Myeloid | Stromal | Treg | CD4 Tcells | CD8 Tcells | Monocytes | Macrophages | cDC2 | cDC1 |
|---|---|---|---|---|---|---|---|---|---|
| Variable | Variable | Low | High | High | Low | Low | Variable | High | Low |
Potential Origin of this Archetype
Epithelial homestasis in the Stromal Treg axis sustained by IFN/CCR2 TGFb
Archetype Tumor transcriptomic program
ER Stress (CH25H, ERN2)
Archetype Chemokines Expressed
CCL17, CCL18, CCR4, CCR8
Archetype Immune Transcriptomic Programs
TGFb signaling , enriched in DC3 anfd resting Tregs
Immune Archetype Gene Signature
Table of Archetype Feature Scores
Table of Archetype Feature Flow Populations
Table of Archetype non feature Flow Populations
Histology Abbreviations
ADC = Adenocarcinoma NOS PC = Papillary Carcinoma NOS C = Carcinoma NOS CCC = Clear Cell Adenocarcinoma NOS
| Sample | Gender | Race | Ethnicity | BMI | Age | T Stage | N Stage | M Stage | Grade | Histology | Tumor type | Extraction Site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IPIBLAD026.T1 | Male | Other | Non Hispanic or Latino | 31 | 61 | 1 | 0 | X | G3: Poorly differentiated (high grade) | Clear Cell Adenocarcinoma NOS | Primary | Ureter |
| IPICRC087.T1 | Female | White | Non Hispanic or Latino | 17.83 | 70 | 3 | 0 | G2: Moderately differentiated (intermediate grade) | ADC | Primary | ascending colon | |
| IPICRC088.T1 | Male | Asian | Non Hispanic or Latino | 16.64 | 83 | 4a | 2 | 1 | G2: Moderately differentiated (intermediate grade) | ADC | Primary | ascending colon |
| IPICRC090.T1 | Male | White | Non Hispanic or Latino | 25.9 | 36 | 3 | 1b | G2: Moderately differentiated (intermediate grade) | ADC | Primary | rectum | |
| IPIGYN013.T1 | Female | Asian | Non Hispanic or Latino | 19.66 | 59 | 1 | 0 | G3: Poorly differentiated (high grade) | CCC | Primary | ovary | |
| IPIKID108.T1 | Male | Asian | Non Hispanic or Latino | 27 | 54 | 3b | 0 | G3: Poorly differentiated (high grade) | PC | Primary | right kidney | |
| IPILUNG008.T1 | Female | White | Non Hispanic or Latino | 20 | 72 | 1a | 0 | G1: Well differentiated (low grade) | ADC | Primary | upper lobe of right lung | |
| IPILUNG013.T1 | Male | White | Non Hispanic or Latino | 22 | 80 | 1b | 1 | G2: Moderately differentiated (intermediate grade) | ADC | Primary | upper lobe of left lung | |
| IPILUNG014.T1 | Female | Black or African American | Non Hispanic or Latino | 20 | 81 | 1b | 1 | G3: Poorly differentiated (high grade) | ADC | Primary | upper lobe of left lung | |
| IPILUNG015.T1 | Male | White | Non Hispanic or Latino | 28 | 83 | 1a | 0 | G2: Moderately differentiated (intermediate grade) | ADC | Primary | ||
| IPILUNG030.T1 | Female | Other | Non Hispanic or Latino | 39 | 61 | 1b | 0 | G3: Poorly differentiated (high grade) | ADC | Primary | ||
| IPILUNG041.T1 | Female | Asian | Non Hispanic or Latino | 28 | 79 | 2a | 2 | G2: Moderately differentiated (intermediate grade) | ADC | Primary | lower lobe of right lung | |
| IPILUNG054.T1 | Female | White | Non Hispanic or Latino | 33 | 76 | 1a | X | G2: Moderately differentiated (intermediate grade) | ADC | Primary | upper lobe of right lung | |
| IPILUNG058.T1 | Male | White | Non Hispanic or Latino | 30 | 75 | 1b | X | G2: Moderately differentiated (intermediate grade) | ADC | Primary | upper lobe of left lung | |
| IPILUNG069.T1 | Male | White | Non Hispanic or Latino | 27 | 63 | 1b | 2 | G3: Poorly differentiated (high grade) | ADC | Primary | upper lobe of right lung | |
| IPILUNG076.T1 | Female | Asian | Non Hispanic or Latino | 20 | 59 | 2a | 0 | G2: Moderately differentiated (intermediate grade) | ADC | Primary | upper lobe of right lung | |
| IPILUNG080.T1 | Male | Asian | Non Hispanic or Latino | 25 | 69 | 2a | 1 | G3: Poorly differentiated (high grade) | ADC | Primary | lower lobe of right lung | |
| IPIMEL252.T1 | Male | White | Non Hispanic or Latino | 18 | 61 | 3b | 3 | 0 | Not Available | Nevi & Melanomas | Primary | right arm |
| IPIMEL253.T1 | Male | White | Non Hispanic or Latino | 30 | 62 | 4b | X | 1c | Not Available | Nevi & Melanomas | Metastasis | retroperitoneal lymph node |
| IPIMEL255.T1 | Male | White | Non Hispanic or Latino | 36 | 48 | 4b | 2 | 0 | Not Available | Nevi & Melanomas | Metastasis | Left axilla, sentinel lymph node |