Immune Stromal Rich CD4 Macrophage Bias

Archetype Feature Distributions
Tcells  Myeloid  Stromal  Treg   CD4 Tcells   CD8 Tcells Monocytes  Macrophages  cDC2 cDC1
Variable HIgh High Very High HIgh Low Low Very High Variable Low


Potential Origin of this Archetype

Tissue repair, Senescence, Tissue resident T cells, M2-like Macrophage, Sustained by IFN and TGFB signalling

Archetype Tumor transcriptomic program

IFN Signalling, SASP, Tissue repair

Archetype Chemokines Expressed

CCL2, CCR2, CCL17, CCL16, CCL19, CCL21, CCL22, CCR6, CCR7, CXCL9, CXCL11, CXCL12, CXCR3, CXCR4

Archetype Immune Transcriptomic Programs

M2-like phenotype, Tissue repair, Mast cells, IFN stimulated gene in myeloid cells

Immune Archetype Gene Signature 

Table of Archetype Feature Scores

Table of Archetype FEATURE flow Populations         

Table of Archetype non feature flow Populations

Histology Abbreviations

ADC = Adenocarcinoma NOS    PSC = Papillary  Serous Cystadenocarcinoma    SCC = Squamous Cell Carcinoma NOS  CCC = Clear Cell Carcinoma NOS   EA = Endometriod Adenocarcinoma  GST =  Gastrointestinal stroma tumor

SampleGenderRaceEthnicityBMIAgeT StageN StageM StageGradeHistologyTumor typeExtraction Site
IPICRC055.T1FemaleWhiteNon Hispanic or Latino29.638131G2: Moderately differentiated (intermediate grade)ADCPrimarysigmoid colon
IPIGYN045.T1FemaleWhiteNon Hispanic or Latino31.5379Not AvailableNot AvailableNot AvailableG3: Poorly differentiated (high grade)PSCPrimaryuterus
IPIGYN069.T1FemaleWhiteNon Hispanic or Latino23.7869310G1: Well differentiated (low grade)GSTPrimaryovary
IPIGYN082.T1FemaleBlack or African AmericanNon Hispanic or Latino34.39643bX1G3: Poorly differentiated (high grade)PSCPrimaryuterus
IPIGYN089.T1FemaleOtherHispanic or Latino52501a0G1: Well differentiated (low grade)EAPrimaryuterus
IPIHNSC050.T1MaleWhiteNon Hispanic or Latino14.31694a20G2: Moderately differentiated (intermediate grade)SCCPrimaryoral Cavity
IPIHNSC057.T1FemaleBlack or African AmericanNon Hispanic or Latino26.0463220G2: Moderately differentiated (intermediate grade)SCCPrimaryoral Cavity
IPIHNSC075.T1MaleWhiteNon Hispanic or Latino25.375200G3: Poorly differentiated (high grade)ADCPrimarymajor salivary gland
IPIKID061.T1MaleWhiteNon Hispanic or Latino216941G3: Poorly differentiated (high grade)OtherPrimaryright kidney
IPIKID098.T1MaleWhiteHispanic or Latino22593a1Not AvailableCCCPrimaryright kidney
IPILUNG062.T1FemaleWhiteNon Hispanic or Latino34731bXG2: Moderately differentiated (intermediate grade)ADCPrimaryupper lobe of right lung
IPILUNG074.T1FemaleAsianNon Hispanic or Latino23.8572a2G3: Poorly differentiated (high grade)ADCPrimaryupper lobe of left lung