Archetype Feature Distributions
| Tcells | Myeloid | Stromal | Treg | CD4 Tcells | CD8 Tcells | Monocytes | Macrophages | cDC2 | cDC1 |
|---|---|---|---|---|---|---|---|---|---|
| Low | Variable | High | Variable | Variable | Variable | Low | Low | Very High | High |
Potential Origin of this Archetype
Immune Priveleged tissue, Myeloid, stromal, ECM axis, Sustained by IL10 and Steroid signalling
Archetype Tumor transcriptomic program
ER Stress (ATF3), Estrogen signalling
Archetype Chemokines Expressed
CXC3CL1, CXCR3, CXCl17, CCR6, CCL26, CCR3
Archetype Immune Transcriptomic Programs
High in Ag-Presentation/Co-Stim, High DC3
Immune Archetype Gene Signature
Table of Archetype Feature Scores
Table of Archetype FEATURE flow Populations
Table of Archetype non feature flow Populations
Histology Abbreviations
ADC = Adenocarcinoma NOS PSC = Papillary Serous Cystadenocarcinoma C = Carcinoma NOS MCC = Merkel Cell Carcinoma NOS ACC = Acinic Cell Carcinoma EA = Endometriod Adenocarcinoma NET = Neuroendocrine Tumor GST = Gastrointestinal stroma tumor
| Sample | Gender | Race | Ethnicity | BMI | Age | T Stage | N Stage | M Stage | Grade | Histology | Tumor type | Extraction Site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IPICRC040.T2 | Female | White | Non Hispanic or Latino | 22.66 | 68 | 4 | 0 | 0 | G2: Moderately differentiated (intermediate grade) | ADC | Regional Recurrence | right colon |
| IPICRC079.T1 | Male | Asian | Non Hispanic or Latino | 31.77 | 41 | 2 | 0 | G1: Well differentiated (low grade) | GST | Primary | duodenum | |
| IPICRC093.T1 | Male | White | Non Hispanic or Latino | 25.24 | 51 | 2 | 0 | G2: Moderately differentiated (intermediate grade) | ADC | Primary | rectum | |
| IPIGYN003.T1 | Female | Other | Hispanic or Latino | 24 | 63 | 1a | X | G2: Moderately differentiated (intermediate grade) | EA | Primary | endometrium | |
| IPIGYN078.T1 | Female | White | Non Hispanic or Latino | 33.06 | 69 | 1b | X | Not Available | EA | Primary | uterus | |
| IPIGYN087.T1 | Female | White | Non Hispanic or Latino | 25 | 41 | 1a | 0 | G2: Moderately differentiated (intermediate grade) | ADC | Primary | ovary | |
| IPIGYN124.T1 | Female | White | Non Hispanic or Latino | 24 | 79 | 3c | X | G3: Poorly differentiated (high grade) | PSC | Primary | ||
| IPIHNSC078.T1 | Female | White | Non Hispanic or Latino | 25.8 | 57 | 3 | 0 | 0 | G3: Poorly differentiated (high grade) | ACC | Primary | major salivary gland |
| IPIKID097.T1 | Female | White | Non Hispanic or Latino | 26 | 44 | 3a | 1 | 1 | Not Available | Other | left kidney | |
| IPILUNG021.T1 | Female | Asian | Non Hispanic or Latino | 27 | 69 | 1b | 0 | G2: Moderately differentiated (intermediate grade) | ADC | Primary | lower lobe of right lung | |
| IPIMEL113.T1 | Female | White | Non Hispanic or Latino | 24 | 89 | 1a | 1a | 0 | Not Available | MCC | Metastasis | groin |
| IPIMEL271.T1 | Male | White | Non Hispanic or Latino | 27 | 65 | X | 2 | 1c | Not Available | Nevi & Melanomas | Metastasis | right axilla |
| IPIPDAC037.T1 | Male | White | Hispanic or Latino | 24 | 64 | 3 | 1 | G2: Moderately differentiated (intermediate grade) | ADC | Primary | Pancreas | |
| IPIPNET014.T1 | Female | Other | Non Hispanic or Latino | 23 | 61 | 2 | 1 | G1: Well differentiated (low grade) | NET | Primary | Pancreas | |
| IPIPNET016.T1 | Female | White | Non Hispanic or Latino | 29 | 59 | 2 | 0 | G1: Well differentiated (low grade) | C | Primary |