Archetype Feature Distributions
| Tcells | Myeloid | Stromal | Treg | CD4 Tcells | CD8 Tcells | Monocytes | Macrophages | cDC2 | cDC1 |
|---|---|---|---|---|---|---|---|---|---|
| High | low | Variable | Very High | HIgh | Medium | Low | Variable | Variable | Variable |
Potential Origin of this Archetype
Mucosal homeostasis, Treg-Plasma cells axis, Sustained by CXL13 signalling
Archetype Tumor transcriptomic program
IFN Signalling
Archetype Chemokines Expressed
CXCL13, CXCR5, XCL1, XCL2, XCR1
Archetype Immune Transcriptomic Programs
High in Plasma cells, IFN siganlling, High Exhaustion, Suppresive Tregs, High Ag-Presentation/Co-Stim
Immune Archetype Gene Signature
Table of Archetype Feature Scores
Table of Archetype feature flow Populations
TABLE of archetype non feature flow populations
Histology Abbreviations
ADC = Adenocarcinoma NOS PSC = Papillary Serous Cystadenocarcinoma SCC = Squamous Cell Carcinoma NOS CCC = Clear Cell Carcinoma NOS TCC = Transitional Cell Carcinoma NOS MA = Mucinous Adenocarcinoma HC = Hepatocellular Carcinoma, NOS
| Sample | Gender | Race | Ethnicity | BMI | Age | T Stage | N Stage | M Stage | Grade | Histology | Tumor type | Extraction Site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IPIBLAD029.T1 | Male | Other | Hispanic or Latino | 21 | 61 | 4a | 3 | G3: Poorly differentiated (high grade) | SCC | Primary | Bladder | |
| IPIBLAD036.T1 | Male | Asian | Non Hispanic or Latino | 23 | 73 | 2a | 0 | G3: Poorly differentiated (high grade) | TCC | Primary | Bladder | |
| IPICRC048.T1 | Male | White | Non Hispanic or Latino | 22.64 | 87 | 3 | 0 | G2: Moderately differentiated (intermediate grade) | MA | Primary | ascending colon | |
| IPICRC070.T1 | Female | Asian | Non Hispanic or Latino | 26.35 | 68 | 3 | 0 | 0 | G2: Moderately differentiated (intermediate grade) | ADC | Primary | descending colon |
| IPIGYN027.T1 | Female | White | Non Hispanic or Latino | 24.76 | 73 | 3c | 1 | G3: Poorly differentiated (high grade) | PSC | Primary | ||
| IPIGYN104.T1 | Female | American Indian or Alaskan Native | Non Hispanic or Latino | 29 | 63 | 3c | X | G3: Poorly differentiated (high grade) | PSC | Primary | uterus | |
| IPIHEP003.T1 | Male | Black or African American | Non Hispanic or Latino | 25 | 77 | 3a | X | G3: Poorly differentiated (high grade) | HC | Primary | liver | |
| IPIHEP013.T1 | Male | Asian | Non Hispanic or Latino | 26 | 68 | 1 | X | GX: Grade cannot be assessed (undetermined grade) | HC | Primary | liver | |
| IPIHNSC030.T1 | Female | Other | Hispanic or Latino | 37.6 | 21 | 2 | 1 | G2: Moderately differentiated (intermediate grade) | SCC | Primary | ||
| IPIHNSC056.T1 | Female | White | Not reported | 36.37 | 45 | 3 | 2 | 0 | G2: Moderately differentiated (intermediate grade) | SCC | Primary | oral Cavity |
| IPIHNSC059.T1 | Male | White | Non Hispanic or Latino | 30.77 | 58 | 4a | 2 | 0 | G2: Moderately differentiated (intermediate grade) | SCC | LocalRecurrence | left part of face |
| IPIHNSC060.T1 | Male | White | Non Hispanic or Latino | 29.34 | 79 | 3 | 2 | 0 | G2: Moderately differentiated (intermediate grade) | SCC | Primary | oral Cavity |
| IPIHNSC074.T1 | Female | Other | Hispanic or Latino | 22 | 78 | 3 | 3 | 0 | G3: Poorly differentiated (high grade) | SCC | Primary | oral cavity |
| IPIHNSC079.T1 | Male | White | Non Hispanic or Latino | 20.91 | 57 | 4a | 0 | 0 | G1: Well differentiated (low grade) | SCC | Primary | oral cavity |
| IPIKID049.T1 | Female | White | Hispanic or Latino | 40 | 80 | 3a | X | G3: Poorly differentiated (high grade) | CCC | Primary | left kidney | |
| IPIKID085.T1 | Male | White | Non Hispanic or Latino | 34 | 78 | 3a | 0 | G3: Poorly differentiated (high grade) | CCC | Primary | left kidney | |
| IPIKID086.T2 | Male | White | Non Hispanic or Latino | 34 | 69 | 3a | 0 | G3: Poorly differentiated (high grade) | CCC | Primary | right kidney | |
| IPILUNG037.T1 | Female | White | Non Hispanic or Latino | 24 | 58 | 2a | 1 | G3: Poorly differentiated (high grade) | ADC | Primary | upper lobe of right lung | |
| IPILUNG052.T1 | Female | White | Non Hispanic or Latino | 24 | 69 | 2a | 1 | G3: Poorly differentiated (high grade) | ADC | Primary | upper lobe of right lung | |
| IPILUNG056.T1 | Male | White | Non Hispanic or Latino | 24 | 86 | 2 | X | G3: Poorly differentiated (high grade) | ADC | Primary | lower lobe of left lung | |
| IPILUNG088.T1 | Female | White | Non Hispanic or Latino | 37 | 73 | 2b | 2 | G2: Moderately differentiated (intermediate grade) | SCC | Primary | lower lobe of left lung | |
| IPIMEL212.T1 | Male | White | Non Hispanic or Latino | 26 | 40 | 1a | 3 | 1b | Not Available | Nevi & Melanomas | Metastasis | left axilla lymph node |
| IPIMEL274.T1 | Male | White | Non Hispanic or Latino | 36 | 70 | 1 | 2 | 1c | Not Available | Not Available | Metastasis | left inguinal lymph node |