Tcell Centric Macrophage Bias

Archetype Feature Distributions
Tcells  Myeloid  Stromal  Treg   CD4 Tcells   CD8 Tcells Monocytes  Macrophages  cDC2 cDC1
High low Variable Very High HIgh Medium Low Variable Variable Variable

 


Potential Origin of this Archetype

Mucosal homeostasis, Treg-Plasma cells axis, Sustained by CXL13 signalling

Archetype Tumor transcriptomic program

IFN Signalling

Archetype Chemokines Expressed

CXCL13, CXCR5, XCL1, XCL2, XCR1

Archetype Immune Transcriptomic Programs

High in Plasma cells, IFN siganlling, High Exhaustion, Suppresive Tregs, High Ag-Presentation/Co-Stim


 

Table of Archetype flow Populations      Immune Archetype Gene Signature      Table of Archetype Feature Scores

 


Histology Abbreviations

ADC = Adenocarcinoma NOS    PSC = Papillary  Serous Cystadenocarcinoma    SCC = Squamous Cell Carcinoma NOS  CCC = Clear Cell Carcinoma NOS  TCC = Transitional Cell Carcinoma NOS  MA = Mucinous Adenocarcinoma HC = Hepatocellular Carcinoma, NOS

SampleGenderRaceEthnicityBMIAgeT StageN StageM StageGradeHistologyTumor typeExtraction Site
IPIBLAD029.T1MaleOtherHispanic or Latino21614a3G3: Poorly differentiated (high grade)SCCPrimaryBladder
IPIBLAD036.T1MaleAsianNon Hispanic or Latino23732a0G3: Poorly differentiated (high grade)TCCPrimaryBladder
IPICRC048.T1MaleWhiteNon Hispanic or Latino22.648730G2: Moderately differentiated (intermediate grade)MAPrimaryascending colon
IPICRC070.T1FemaleAsianNon Hispanic or Latino26.3568300G2: Moderately differentiated (intermediate grade)ADCPrimarydescending colon
IPIGYN027.T1FemaleWhiteNon Hispanic or Latino24.76733c1G3: Poorly differentiated (high grade)PSCPrimary
IPIGYN104.T1FemaleAmerican Indian or Alaskan NativeNon Hispanic or Latino29633cXG3: Poorly differentiated (high grade)PSCPrimaryuterus
IPIHEP003.T1MaleBlack or African AmericanNon Hispanic or Latino25773aXG3: Poorly differentiated (high grade)HCPrimaryliver
IPIHEP013.T1MaleAsianNon Hispanic or Latino26681XGX: Grade cannot be assessed (undetermined grade)HCPrimaryliver
IPIHNSC030.T1FemaleOtherHispanic or Latino37.62121G2: Moderately differentiated (intermediate grade)SCCPrimary
IPIHNSC056.T1FemaleWhiteNot reported36.3745320G2: Moderately differentiated (intermediate grade)SCCPrimaryoral Cavity
IPIHNSC059.T1MaleWhiteNon Hispanic or Latino30.77584a20G2: Moderately differentiated (intermediate grade)SCCLocalRecurrenceleft part of face
IPIHNSC060.T1MaleWhiteNon Hispanic or Latino29.3479320G2: Moderately differentiated (intermediate grade)SCCPrimaryoral Cavity
IPIHNSC074.T1FemaleOtherHispanic or Latino2278330G3: Poorly differentiated (high grade)SCCPrimaryoral cavity
IPIHNSC079.T1MaleWhiteNon Hispanic or Latino20.91574a00G1: Well differentiated (low grade)SCCPrimaryoral cavity
IPIKID049.T1FemaleWhiteHispanic or Latino40803aXG3: Poorly differentiated (high grade)CCCPrimaryleft kidney
IPIKID085.T1MaleWhiteNon Hispanic or Latino34783a0G3: Poorly differentiated (high grade)CCCPrimaryleft kidney
IPIKID086.T2MaleWhiteNon Hispanic or Latino34693a0G3: Poorly differentiated (high grade)CCCPrimaryright kidney
IPILUNG037.T1FemaleWhiteNon Hispanic or Latino24582a1G3: Poorly differentiated (high grade)ADCPrimaryupper lobe of right lung
IPILUNG052.T1FemaleWhiteNon Hispanic or Latino24692a1G3: Poorly differentiated (high grade)ADCPrimaryupper lobe of right lung
IPILUNG056.T1MaleWhiteNon Hispanic or Latino24862XG3: Poorly differentiated (high grade)ADCPrimarylower lobe of left lung
IPILUNG088.T1FemaleWhiteNon Hispanic or Latino37732b2G2: Moderately differentiated (intermediate grade)SCCPrimarylower lobe of left lung
IPIMEL212.T1MaleWhiteNon Hispanic or Latino26401a31bNot AvailableNevi & MelanomasMetastasisleft axilla lymph node
IPIMEL274.T1MaleWhiteNon Hispanic or Latino3670121cNot AvailableNot AvailableMetastasisleft inguinal lymph node