NK Cells in Melanoma Data (Barry et al)

 CR = complete response            PD = progressive disease

 PR = partial response                 SD = stable disease

 

Treatment Table

   

Sample Response  IPI IDs Primary site  Stage Pre/Post anti-PD-1 Treatment Prior Ipilimumab Prior Targeted Therapy Prior Radiation Prior Chemotherapy Baseline LDH
1 CR IPIMEL035 Cutaneous IV Post Y Y Y N Normal
2 CR IPIME   L076 Cutaneous IIIC Pre N N N N Normal
3 CR IPIMEL105_T2 Cutaneous IIIC  Post  N N N N Normal
4 CR IPIMEL125 Cutaneous IIIB Post N N N N Normal
5 CR IPIMEL134 Cutaneous IIIB Post N Y N N Normal
6 CR IPIMEL181 Cutaneous IV Pre N N N N Normal
7 CR IPIMEL253 LN IV Post N N N N Elevated
8 CR IPIMEL274 LN IV Post N Y Y N Normal
9 CR IPIMEL276 Cutaneous  IIIB Post N Y N N Normal
10 CR IPIMEL288 Cutaneous IIIA Pre N N N N Normal
11 PR IPIMEL085 Unknown IV Pre Y N Y N Normal
12 PR IPIMEL090 Unknown IV Post  Y N N N Normal
13 PR IPIMEL106 Cutaneous IV Pre N Y Y N Normal
14 PR IPIMEL108 Melanoma Primary IV  Pre N N N N Normal
15 PR IPIMEL127 Mucosal  IV  Post  Y N N N Elevated
16 PR IPIMEL131 Cutaneous IV Pre N N N N Normal
17 SD IPIMEL116_T1 Unknown IV Post N N Y N Normal
18 SD IPIMEL156 Cutaneous IV Post N N N N Elevated
19 SD IPIMEL185 Cutaneous IV Pre N N N N Elevated
20 PD IPIMEL044 Cutaneous IV Post Y N N N Normal
21 PD IPIMEL123_T1 Cutaneous IV Pre N N N N Normal
22 PD IPIMEL147 Cutaneous IV Pre N N N N Normal
23 PD IPIMEL149 Cutaneous IV Post Y Y N N Normal
24 PD IPIMEL155 Cutaneous IIIA Pre N N N N N/A
25 PD IPIMEL191 Cutaneous IIIA Pre N Y N N Normal
26 PD IPIMEL226 Cutaneous IV Post Y Y N N N/A
27 N/A IPIMEL056 Cutaneous IV N/A N N N N N/A
28 N/A IPIMEL221 Skin and Soft Tissue N/A N/A N N N N N/A
29 N/A IPIMEL212 Left axillary lymph nodes,  IIIC N/A N N N N N/A
30 N/A IPIMEL069 Cutaneous III N/A N N N N N/A
31 N/A IPIMEL113 Merkel Cell Carcinoma
 w/ extensive associated subcutaneous invasion 		 IIIA N/A N N N N N/A

ID Table

Sample Response IPI IDs GEO link for RNAseq Fastgs Used for
heatmap		 WSPs
available
1 CR IPIMEL035   N/A  
2 CR IPIMEL076   X x
3 CR IPIMEL105_T2   X x
4 CR IPIMEL125   X x
5 CR IPIMEL134   N/A  
6 CR IPIMEL181   X x
7 CR IPIMEL253 GSM3097446 X x
8 CR IPIMEL274 GSM3097447 X x
9 CR IPIMEL276   X x
10 CR IPIMEL288   X x
11 PR IPIMEL085 GSM3097440 X x
12 PR IPIMEL090   X x
13 PR IPIMEL106   X x
14 PR IPIMEL108 GSM3097441 X x
15 PR IPIMEL127   X x
16 PR IPIMEL131 GSM3097443 X x
17 SD IPIMEL116_T1   X x
18 SD IPIMEL156   X x
19 SD IPIMEL185   X x
20 PD IPIMEL044   N/A x
21 PD IPIMEL123_T1   X x
22 PD IPIMEL147   X x
23 PD IPIMEL149 GSM3097444 X x
24 PD IPIMEL155   X x
25 PD IPIMEL191   X x
26 PD IPIMEL226   X x
27 N/A IPIMEL056 GSM3097438 N/A X
28 N/A IPIMEL221 GSM3097448 N/A X
29 N/A IPIMEL212 GSM3097445 N/A X
30 N/A IPIMEL069 GSM3097439 N/A x
31 N/A IPIMEL113 GSM3097442 N/A x

 

Flow Fraction Table 

# = very low cell count

 

Sample Response IPI IDs cDC1/HLA DR+ Lin- Nk cells/CD45+ cDC2/HLA DR+ Lin- CD4 Tconv/CD45+ CD4 Treg/CD45+ CD8 T cell/CD45+
           
1 CR IPIMEL035 1.51 1.53 3.66 N/A N/A N/A
2 CR IPIMEL076 2.82 2.06 10.7 24.3 3.02 50
3 CR IPIMEL105_T2 1.56 0.65 9.41 74.2 1.74 18.9
4 CR IPIMEL125 2.62 0.54 9.07 78.3 12.3 8.02
5 CR IPIMEL134 2.57 N/A N/A N/A N/A N/A
6 CR IPIMEL181 2.51 1.29 22.2 63.7 11.5 14.5
7 CR IPIMEL253 2.51 2.55 7.9 51.3 8.33 18
8 CR IPIMEL274 5.35 1.22 5.23 33.1 11.8 48.7
9 CR IPIMEL276 0.53 3.25 12.5 12.3 8.02 4.77
10 CR IPIMEL288 2.13 2.17 21.6 65.2 9.42 17
11 PR IPIMEL085 2.79 1 29.9 81.4 6.98 7.32
12 PR IPIMEL090 1.07 0.46 17.2 62.5 2.53 29
13 PR IPIMEL106 5.59 5.99 2.8 34.8 4.93 43
14 PR IPIMEL108 2.41 2.78 9.13 7.06 0.75 5.81
15 PR IPIMEL127 5.19 6.76 12.5 19.4 12.9 37.9
16 PR IPIMEL131 3.05 3.74 4.57 26.1 1.6 56.9
17 SD IPIMEL116_T1 0.44 0.53 0.64 5.48 2.44 2.91E-03
18 SD IPIMEL156 0.95 1.26 4.25 6.68 1.07 0.11
19 SD IPIMEL185 #1.56 #3.04 #6.77 #0.039 #0.061 #0.005
20 PD IPIMEL044 1.35 N/A 16.2 N/A N/A N/A
21 PD IPIMEL123_T1 1.68 0.53 14 56.4 6.75 29
22 PD IPIMEL147 0.37 0.09 18.9 0.1 0.023 6.40E-01
23 PD IPIMEL149 0.29 0.92 6.66 N/A N/A N/A
24 PD IPIMEL155 0.4 N/A 7.63 N/A N/A N/A
25 PD IPIMEL191 0.96 0.68 10.3 36.7 1.21 6.51
26 PD IPIMEL226 0.9 1.23 4.56 17.7 9.36 68
27 N/A IPIMEL056 1.49 0.77 5.7 N/A N/A N/A
28 N/A IPIMEL221 0.44 0.6 0.76 N/A N/A N/A
29 N/A IPIMEL212 4.24 2.23 13.1 N/A N/A N/A
30 N/A IPIMEL069 0.29 0.6 0.83 N/A N/A N/A
31 N/A IPIMEL113 3.13 3.6 24.3 N/A N/A N/A