Archetype Feature Distributions
| Tcells | Myeloid | Stromal | Treg | CD4 Tcells | CD8 Tcells | Monocytes | Macrophages | cDC2 | cDC1 |
|---|---|---|---|---|---|---|---|---|---|
| Low | Variable | High | Low | Variable | Low | Low | Very High | Variable | Low |
Potential Origin of this Archetype
Central Nervous System, Tissue resident T cells, Macrophage Axis, Sustained by CXCR2 signalling
Archetype Tumor transcriptomic program
Cell cycle (G1-S), Nervous system
Archetype Chemokines Expressed
CXCl17, CCR6, CXCL1, CXR2
Archetype Immune Transcriptomic Programs
Tissue resident T cells (Trem), Th17 like, IL10, TNFa, IL1 Signalling
Immune Archetype Gene Signature
Table of Archetype Feature Scores
Table of Archetype feature flow Populations
Table of Archetype non feature flow Populations
Histology Abbreviations
ADC = Adenocarcinoma NOS PSC = Papillary Serous Cystadenocarcinoma PC = Papillary Carcinoma C = Carcinoma NOS SC = Small Cell Carcinoma NOS CCC = Clear Cell Carcinoma NOS EA = Endometriod Adenocarcinoma NET = Neuroendocrine Tumor TCC = Transitional Cell Carcinoma NOS, MES = Mesothelioma Malignant MA = Mucinous Adenocarcinoma G= Glioblastoma, NOS
| Sample | Gender | Race | Ethnicity | BMI | Age | T Stage | N Stage | M Stage | Grade | Histology | Tumor type | Extraction Site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IPIBLAD033.T1 | Male | White | Non Hispanic or Latino | 29 | 62 | 1a | 0 | G3: Poorly differentiated (high grade) | TCC | Regional Recurrence | Bladder | |
| IPICRC067.T1 | Female | White | Non Hispanic or Latino | 32.49 | 53 | 1 | 0 | 0 | G2: Moderately differentiated (intermediate grade) | ADC | Primary | sigmoid colon |
| IPICRC071.T2 | Male | White | Non Hispanic or Latino | 37.76 | 54 | 0 | 1 | G2: Moderately differentiated (intermediate grade) | ADC | LocalRecurrence | ||
| IPICRC073.T1 | Female | Other | Hispanic or Latino | 24.87 | 50 | 4a | 0 | GX: Grade cannot be assessed (undetermined grade) | ADC | Primary | sigmoid colon | |
| IPICRC076.T1 | Male | White | Non Hispanic or Latino | 21.61 | 57 | 4b | 1 | G1: Well differentiated (low grade) | ADC | Primary | rectosigmoid junction | |
| IPICRC078.T2 | Female | White | Non Hispanic or Latino | 22.89 | 58 | Not Available | Not Available | Not Available | G1: Well differentiated (low grade) | NET | Primary | colon |
| IPIGBM006.T1 | Female | White | Non Hispanic or Latino | 27.82 | 54 | Not Available | Not Available | Not Available | G4: Undifferentiated (high grade) | G | Primary | right frontal lobe |
| IPIGYN015.T1 | Female | Other | Non Hispanic or Latino | 15.44 | 47 | 1c | 0 | G2: Moderately differentiated (intermediate grade) | EA | LocalRecurrence | ovary | |
| IPIGYN019.T1 | Female | Other | Hispanic or Latino | 37.4 | 59 | 3c | X | G3: Poorly differentiated (high grade) | C | Primary | ovary | |
| IPIGYN021.T1 | Female | White | Non Hispanic or Latino | 23.41 | 66 | 2c | 1 | G3: Poorly differentiated (high grade) | PSC | Primary | ||
| IPIGYN040.T1 | Female | Other | Hispanic or Latino | 41.33 | 66 | 1a | 0 | G2: Moderately differentiated (intermediate grade) | EA | Primary | ||
| IPIGYN043.T1 | Female | White | Non Hispanic or Latino | 50.63 | 38 | 1a | X | G1: Well differentiated (low grade) | EA | Primary | uterus | |
| IPIGYN060.T1 | Female | White | Non Hispanic or Latino | 27.05 | 54 | 2a | 0 | G3: Poorly differentiated (high grade) | PSC | Primary | ovary | |
| IPIGYN083.T1 | Female | White | Hispanic or Latino | 33.62 | 61 | 1a | X | G1: Well differentiated (low grade) | EA | Primary | uterus | |
| IPIGYN091.T1 | Female | White | Non Hispanic or Latino | 33 | 54 | Not Available | Not Available | Not Available | G3: Poorly differentiated (high grade) | MA | Metastasis | ovary |
| IPIGYN093.T1 | Female | Other | Hispanic or Latino | 46 | 31 | 3a | X | G1: Well differentiated (low grade) | EA | Primary | uterus | |
| IPIGYN095.T1 | Female | Other | Non Hispanic or Latino | 31 | 53 | Not Available | Not Available | Not Available | Not Available | MA | Primary | pelvic region element |
| IPIGYN098.T1 | Female | White | Non Hispanic or Latino | 18 | 56 | Not Available | Not Available | Not Available | Not Available | Denuded benign cyst | Primary | uterus |
| IPIGYN103.T1 | Female | White | Non Hispanic or Latino | 48 | 60 | 1a | 0 | G1: Well differentiated (low grade) | EA | Primary | uterus | |
| IPIGYN106.T1 | Female | White | Non Hispanic or Latino | 33 | 60 | 3b | 0 | G3: Poorly differentiated (high grade) | EA | Primary | ||
| IPIGYN107.T1 | Female | Other | Hispanic or Latino | 25 | 39 | 2 | X | G3: Poorly differentiated (high grade) | C | Primary | uterus | |
| IPIGYN108.T1 | Female | White | Non Hispanic or Latino | 27 | 70 | 1a | 0 | G1: Well differentiated (low grade) | EA | Primary | uterus | |
| IPIGYN116.T1 | Female | American Indian or Alaskan Native | Non Hispanic or Latino | 32 | 69 | 2a | 0 | G3: Poorly differentiated (high grade) | OSC | Primary | fallopian tube | |
| IPIGYN125.T1 | Female | White | Non Hispanic or Latino | 41 | 62 | 1b | 1 | 0 | G1: Well differentiated (low grade) | EA | Primary | uterus |
| IPIHNSC069.T1 | Male | Asian | Non Hispanic or Latino | 37.66 | 47 | 2 | 0 | 0 | G3: Poorly differentiated (high grade) | ADC | Primary | major salivary gland |
| IPIKID062.T1 | Male | White | Non Hispanic or Latino | 30 | 66 | 3a | X | G3: Poorly differentiated (high grade) | CCC | Primary | right kidney | |
| IPIKID067.T1 | Female | White | Hispanic or Latino | 27 | 80 | 3a | 0 | GX: Grade cannot be assessed (undetermined grade) | CCC | Primary | right kidney | |
| IPIKID073.T1 | Male | White | Non Hispanic or Latino | 30 | 60 | 1a | 0 | G1: Well differentiated (low grade) | PC | Primary | left kidney | |
| IPIKID110.T1 | Male | White | Non Hispanic or Latino | 24 | 72 | 2b | 1 | G4: Undifferentiated (high grade) | Other | Primary | right kidney | |
| IPILUNG049.T1 | Male | Asian | Non Hispanic or Latino | 27 | 55 | 3 | 2 | Not Available | MES | Primary | left lung | |
| IPILUNG055.T1 | Female | White | Non Hispanic or Latino | 29 | 70 | 1b | 0 | G3: Poorly differentiated (high grade) | SC | LocalRecurrence | lower lobe of left lung |