Immune Desert CD4 Macrophage Bias

Archetype Feature Distributions
Tcells  Myeloid  Stromal  Treg   CD4 Tcells   CD8 Tcells Monocytes  Macrophages  cDC2 cDC1
Low Variable High Low Variable Low Low Very High Variable Low

 


Potential Origin of this Archetype

Central Nervous System, Tissue resident T cells, Macrophage Axis, Sustained by CXCR2 signalling

Archetype Tumor transcriptomic program

Cell cycle (G1-S), Nervous system

Archetype Chemokines Expressed

CXCl17, CCR6, CXCL1, CXR2

Archetype Immune Transcriptomic Programs

Tissue resident T cells (Trem), Th17 like, IL10, TNFa, IL1 Signalling


 

Table of Archetype flow Populations      Immune Archetype Gene Signature      Table of Archetype Feature Scores

 


Histology Abbreviations

ADC = Adenocarcinoma NOS    PSC = Papillary  Serous Cystadenocarcinoma   PC = Papillary  Carcinoma  C = Carcinoma NOS  SC = Small Cell Carcinoma NOS  CCC = Clear Cell Carcinoma NOS   EA = Endometriod Adenocarcinoma  NET = Neuroendocrine Tumor  TCC = Transitional Cell Carcinoma NOS, MES = Mesothelioma Malignant MA = Mucinous Adenocarcinoma  G= Glioblastoma, NOS

SampleGenderRaceEthnicityBMIAgeT StageN StageM StageGradeHistologyTumor typeExtraction Site
IPIBLAD033.T1MaleWhiteNon Hispanic or Latino29621a0G3: Poorly differentiated (high grade)TCCRegional RecurrenceBladder
IPICRC067.T1FemaleWhiteNon Hispanic or Latino32.4953100G2: Moderately differentiated (intermediate grade)ADCPrimarysigmoid colon
IPICRC071.T2MaleWhiteNon Hispanic or Latino37.765401G2: Moderately differentiated (intermediate grade)ADCLocalRecurrence
IPICRC073.T1FemaleOtherHispanic or Latino24.87504a0GX: Grade cannot be assessed (undetermined grade)ADCPrimarysigmoid colon
IPICRC076.T1MaleWhiteNon Hispanic or Latino21.61574b1G1: Well differentiated (low grade)ADCPrimaryrectosigmoid junction
IPICRC078.T2FemaleWhiteNon Hispanic or Latino22.8958Not AvailableNot AvailableNot AvailableG1: Well differentiated (low grade)NETPrimarycolon
IPIGBM006.T1FemaleWhiteNon Hispanic or Latino27.8254Not AvailableNot AvailableNot AvailableG4: Undifferentiated (high grade)GPrimaryright frontal lobe
IPIGYN015.T1FemaleOtherNon Hispanic or Latino15.44471c0G2: Moderately differentiated (intermediate grade)EALocalRecurrenceovary
IPIGYN019.T1FemaleOtherHispanic or Latino37.4593cXG3: Poorly differentiated (high grade)CPrimaryovary
IPIGYN021.T1FemaleWhiteNon Hispanic or Latino23.41662c1G3: Poorly differentiated (high grade)PSCPrimary
IPIGYN040.T1FemaleOtherHispanic or Latino41.33661a0G2: Moderately differentiated (intermediate grade)EAPrimary
IPIGYN043.T1FemaleWhiteNon Hispanic or Latino50.63381aXG1: Well differentiated (low grade)EAPrimaryuterus
IPIGYN060.T1FemaleWhiteNon Hispanic or Latino27.05542a0G3: Poorly differentiated (high grade)PSCPrimaryovary
IPIGYN083.T1FemaleWhiteHispanic or Latino33.62611aXG1: Well differentiated (low grade)EAPrimaryuterus
IPIGYN091.T1FemaleWhiteNon Hispanic or Latino3354Not AvailableNot AvailableNot AvailableG3: Poorly differentiated (high grade)MAMetastasisovary
IPIGYN093.T1FemaleOtherHispanic or Latino46313aXG1: Well differentiated (low grade)EAPrimaryuterus
IPIGYN095.T1FemaleOtherNon Hispanic or Latino3153Not AvailableNot AvailableNot AvailableNot AvailableMAPrimarypelvic region element
IPIGYN098.T1FemaleWhiteNon Hispanic or Latino1856Not AvailableNot AvailableNot AvailableNot AvailableDenuded benign cystPrimaryuterus
IPIGYN103.T1FemaleWhiteNon Hispanic or Latino48601a0G1: Well differentiated (low grade)EAPrimaryuterus
IPIGYN106.T1FemaleWhiteNon Hispanic or Latino33603b0G3: Poorly differentiated (high grade)EAPrimary
IPIGYN107.T1FemaleOtherHispanic or Latino25392XG3: Poorly differentiated (high grade)CPrimaryuterus
IPIGYN108.T1FemaleWhiteNon Hispanic or Latino27701a0G1: Well differentiated (low grade)EAPrimaryuterus
IPIGYN116.T1FemaleAmerican Indian or Alaskan NativeNon Hispanic or Latino32692a0G3: Poorly differentiated (high grade)OSCPrimaryfallopian tube
IPIGYN125.T1FemaleWhiteNon Hispanic or Latino41621b10G1: Well differentiated (low grade)EAPrimaryuterus
IPIHNSC069.T1MaleAsianNon Hispanic or Latino37.6647200G3: Poorly differentiated (high grade)ADCPrimarymajor salivary gland
IPIKID062.T1MaleWhiteNon Hispanic or Latino30663aXG3: Poorly differentiated (high grade)CCCPrimaryright kidney
IPIKID067.T1FemaleWhiteHispanic or Latino27803a0GX: Grade cannot be assessed (undetermined grade)CCCPrimaryright kidney
IPIKID073.T1MaleWhiteNon Hispanic or Latino30601a0G1: Well differentiated (low grade)PCPrimaryleft kidney
IPIKID110.T1MaleWhiteNon Hispanic or Latino24722b1G4: Undifferentiated (high grade)OtherPrimaryright kidney
IPILUNG049.T1MaleAsianNon Hispanic or Latino275532Not AvailableMESPrimaryleft lung
IPILUNG055.T1FemaleWhiteNon Hispanic or Latino29701b0G3: Poorly differentiated (high grade)SCLocalRecurrencelower lobe of left lung