Immune Rich CD8 Monocyte Bias

Archetype Feature Distributions
Tcells  Myeloid  Stromal  Treg   CD4 Tcells   CD8 Tcells Monocytes  Macrophages  cDC2 cDC1
High High Low Medium Low Very high Very high Low Variable High

 


Potential Origin of this Archetype

Acute inflamation in NK cells, Monocytes, cDC1, CD8 Tcells sustained by IFN/CCR2 signaling
Acute viral infection

Archetype Tumor transcriptomic program

IFN Signaling, SASP, EMT

Archetype Chemokines Expressed

XCL1, XCL2, XCR1, CXCL2, CXCR1

Archetype Immune Transcriptomic Programs

Very high in NK cells and tissue resident Tregs. Low exhaustion

 


 

Table of Archetype Flow Populations    Immune Archetype Gene Signature   Table of Archetype Feature Scores

 
Histology Abbreviations

C = Carcinoma NOS    LS = Mild Liver Steatosis  CCC = Clear Cell Carcinoma NOS   LMS =  Leiomyosarcoma

SampleGenderRaceEthnicityBMIAgeT StageN StageM StageGradeHistologyTumor typeExtraction Site
IPIBLAD005.T1MaleWhiteNon Hispanic or Latino21773b0G3: Poorly differentiated (high grade)CPrimaryBladder
IPICRC054.T1MaleWhiteNon Hispanic or Latino25.7645Not AvailableNot AvailableNot AvailableNot AvailableLS
IPIKID057.T1FemaleOtherNon Hispanic or Latino42632bXG2: Moderately differentiated (intermediate grade)CCCPrimaryleft kidney
IPIKID069.T1MaleWhiteNon Hispanic or Latino31483a0G3: Poorly differentiated (high grade)CCCPrimaryright kidney
IPIKID071.T1MaleWhiteHispanic or Latino31633b1G2: Moderately differentiated (intermediate grade)CCCPrimaryright kidney
IPIKID077.T1FemaleWhiteNon Hispanic or Latino23871aXG2: Moderately differentiated (intermediate grade)CCCPrimaryleft kidney
IPIKID089.T1FemaleWhiteHispanic or Latino25793a0G4: Undifferentiated (high grade)CCCPrimarykidney
IPIKID095.T1MaleWhiteNon Hispanic or Latino24481a0G2: Moderately differentiated (intermediate grade)CCCPrimaryright kidney
IPIKID103.T1MaleAsianNon Hispanic or Latino21653aXG3: Poorly differentiated (high grade)CCCPrimaryleft kidney
IPIKID104.T1MaleOtherHispanic or Latino29703aXG2: Moderately differentiated (intermediate grade)CCCPrimaryleft kidney
IPIKID109.T1MaleWhiteNon Hispanic or Latino25843a0G3: Poorly differentiated (high grade)CCCPrimaryright kidney
IPISRC011.T1MaleWhiteNon Hispanic or Latino2675Not AvailableNot AvailableNot AvailableG1: Well differentiated (low grade)LMSMetastasisliver