Archetype Feature Distributions
| Tcells | Myeloid | Stromal | Treg | CD4 Tcells | CD8 Tcells | Monocytes | Macrophages | cDC2 | cDC1 |
|---|---|---|---|---|---|---|---|---|---|
| Low | High | High | Variable | High | Low | Very High | Low | High | Very Low |
Potential Origin of this Archetype
Lipid metabolism and adipose, Treg, myeloid,Neutrophils Axis, Sustained by CCR2 and CXCR2 signalling
Archetype Tumor transcriptomic program
Fibrosis, Cell Stress, DNA damage
Archetype Chemokines Expressed
CCL8 CCL11, CCL16, CCR3, CXCL1 CXCL5, CXCL6, CXCL8 CXCR2, CCL2, CCR2, CXCL9, CXCL11, CXCL12 CXCR3 CXCR4
Archetype Immune Transcriptomic Programs
Type 2 Immunity (M2 and Th1), Th17 like suppresive Tregs, Very high Neutrophils
Immune Archetype Gene Signature
Table of Archetype Feature Scores
Table of Archetype feature flow Populations
Table of Archetype non feature flow Populations
Histology Abbreviations
ADC = Adenocarcinoma NOS C = Carcinoma NOS HC = Hepatocellular Carcinoma, NOS NOS CCC = Clear Cell Carcinoma NOS MES = Mesothelioma Malignant
| Sample | Gender | Race | Ethnicity | BMI | Age | T Stage | N Stage | M Stage | Grade | Histology | Tumor type | Extraction Site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IPIBLAD020.T1 | Female | White | Non Hispanic or Latino | 20 | 83 | 4a | 3 | G3: Poorly differentiated (high grade) | C | Primary | Bladder | |
| IPICRC032.T1 | Male | White | Non Hispanic or Latino | 28.33 | 40 | 1 | 0 | 0 | G1: Well differentiated (low grade) | ADC | Primary | transverse colon |
| IPICRC075.T1 | Male | White | Non Hispanic or Latino | 25.88 | 85 | 3 | 0 | G1: Well differentiated (low grade) | ADC | Primary | caecum | |
| IPIHEP015.T1 | Male | White | Non Hispanic or Latino | 38 | 67 | 2 | X | G2: Moderately differentiated (intermediate grade) | HC | Primary | liver | |
| IPIKID094.T2 | Female | White | Non Hispanic or Latino | 25 | 41 | 3b | 0 | 1 | G4: Undifferentiated (high grade) | CCC | Primary | right kidney |
| IPILUNG011.T1 | Male | White | Non Hispanic or Latino | 23 | 77 | Not Available | Not Available | Not Available | Not Available | MES | Primary | pleura |