Myeloid Centric cDC2 Bias

Archetype Feature Distributions
Tcells  Myeloid  Stromal  Treg   CD4 Tcells   CD8 Tcells Monocytes  Macrophages  cDC2 cDC1
Low High High Variable High Low Very High Low High Very Low

 


Potential Origin of this Archetype

Lipid metabolism and adipose, Treg, myeloid,Neutrophils Axis, Sustained by CCR2 and CXCR2 signalling

Archetype Tumor transcriptomic program

Fibrosis, Cell Stress, DNA damage

Archetype Chemokines Expressed

CCL8 CCL11, CCL16, CCR3, CXCL1 CXCL5, CXCL6, CXCL8 CXCR2, CCL2, CCR2, CXCL9, CXCL11, CXCL12 CXCR3 CXCR4

Archetype Immune Transcriptomic Programs

Type 2 Immunity (M2 and Th1), Th17 like suppresive Tregs, Very high Neutrophils


 

Table of Archetype flow Populations      Immune Archetype Gene Signature      Table of Archetype Feature Scores

 


Histology Abbreviations

ADC = Adenocarcinoma NOS    C = Carcinoma NOS  HC = Hepatocellular Carcinoma, NOS NOS  CCC = Clear Cell Carcinoma NOS   MES = Mesothelioma Malignant

SampleGenderRaceEthnicityBMIAgeT StageN StageM StageGradeHistologyTumor typeExtraction Site
IPIBLAD020.T1FemaleWhiteNon Hispanic or Latino20834a3G3: Poorly differentiated (high grade)CPrimaryBladder
IPICRC032.T1MaleWhiteNon Hispanic or Latino28.3340100G1: Well differentiated (low grade)ADCPrimarytransverse colon
IPICRC075.T1MaleWhiteNon Hispanic or Latino25.888530G1: Well differentiated (low grade)ADCPrimarycaecum
IPIHEP015.T1MaleWhiteNon Hispanic or Latino38672XG2: Moderately differentiated (intermediate grade)HCPrimaryliver
IPIKID094.T2FemaleWhiteNon Hispanic or Latino25413b01G4: Undifferentiated (high grade)CCCPrimaryright kidney
IPILUNG011.T1MaleWhiteNon Hispanic or Latino2377Not AvailableNot AvailableNot AvailableNot AvailableMESPrimarypleura