Immune Stromal Rich CD8 Bias

Archetype Feature Distributions
Tcells  Myeloid  Stromal  Treg   CD4 Tcells   CD8 Tcells Monocytes  Macrophages  cDC2 cDC1
Variable Variable High High Low Very High High Variable Low Variable

 


Potential Origin of this Archetype

Chronic inflamation and Tissue repair, Tissue resident CD8 T cells-Treg, Sustained by IFN and TGFB signalling

Archetype Tumor transcriptomic program

TGFb signalling, IFN signalling, Prostaglandin

Archetype Chemokines Expressed

CCL8 CCL11, CCL16, CCR3, CXCL1 CXCL5, CXCL6, CXCL8 CXCR2, CCL2, CCR2, CXCL9, CXCL11, CXCL12 CXCR3 CXCR4

Archetype Immune Transcriptomic Programs

Tissue resident T cells (Trem), High Exhaustion, Suppresive Tregs, Neutrophils


 

Table of Archetype flow Populations      Immune Archetype Gene Signature      Table of Archetype Feature Scores

 


Histology Abbreviations

ADC = Adenocarcinoma NOS    PSC = Papillary  Serous Cystadenocarcinoma   C = Carcinoma NOS  SCC = Squamous Cell Carcinoma NOS  CCC = Clear Cell Carcinoma NOS   EA = Endometriod Adenocarcinoma S = Sarcoma NOS  TCC = Transitional Cell Carcinoma NOS

SampleGenderRaceEthnicityBMIAgeT StageN StageM StageGradeHistologyTumor typeExtraction Site
IPIBLAD006.T1MaleAsianNon Hispanic or Latino23654a2G3: Poorly differentiated (high grade)Not AvailablePrimaryBladder
IPIBLAD014.T1MaleWhiteNon Hispanic or Latino21692b0G3: Poorly differentiated (high grade)CPrimaryBladder
IPIBLAD019.T1FemaleNot ReportedNot reported31643a0G3: Poorly differentiated (high grade)CPrimaryBladder
IPIBLAD028.T1MaleWhiteNon Hispanic or Latino28763b0G3: Poorly differentiated (high grade)TCCPrimaryBladder
IPIBLAD030.T1MaleWhiteNon Hispanic or Latino27753a1G3: Poorly differentiated (high grade)TCCRegional RecurrenceBladder
IPIBLAD034.T1MaleNative Hawaiian or Pacific IslanderNon Hispanic or Latino29764a2G3: Poorly differentiated (high grade)TCCPrimaryBladder
IPICRC063.T1MaleWhiteNon Hispanic or Latino20.4483300G1: Well differentiated (low grade)ADCPrimaryascending colon
IPIGYN065.T1FemaleNative Hawaiian or Pacific IslanderNon Hispanic or Latino55.94591a0G1: Well differentiated (low grade)EAPrimaryuterus
IPIGYN085.T1FemaleWhiteHispanic or Latino21.74542a0G3: Poorly differentiated (high grade)PSCPrimaryovary
IPIGYN086.T1FemaleOtherNot reported28701cXXG1: Well differentiated (low grade)EAPrimaryovary
IPIGYN088.T1FemaleAsianNon Hispanic or Latino26574XG3: Poorly differentiated (high grade)CPrimaryfallopian tube
IPIGYN105.T1FemaleWhiteNon Hispanic or Latino226210G3: Poorly differentiated (high grade)EAPrimaryuterus
IPIGYN110.T1FemaleWhiteNon Hispanic or Latino23803aX1G3: Poorly differentiated (high grade)EAPrimaryuterus
IPIHNSC062.T1MaleWhiteNon Hispanic or Latino26.275332G3: Poorly differentiated (high grade)SCCPrimaryoral Cavity
IPIHNSC063.T1FemaleWhiteNon Hispanic or Latino26.35654a30G3: Poorly differentiated (high grade)SCCPrimaryoral Cavity
IPIHNSC065.T1MaleWhiteNon Hispanic or Latino21.99584a2Not AvailableSCCLocalRecurrencetongue
IPIHNSC070.T1MaleWhiteNon Hispanic or Latino26.9773200Not AvailableSCCPrimaryoropharynx
IPIHNSC076.T1MaleWhiteNon Hispanic or Latino25.178X30Not AvailableSCCLocalRecurrencecutaneous/subcutaneous mechanoreceptor cell
IPIHNSC077.T1MaleWhiteNon Hispanic or Latino18704a00G3: Poorly differentiated (high grade)SCCLocalRecurrencecutaneous/subcutaneous mechanoreceptor cell
IPIKID070.T1MaleWhiteNon Hispanic or Latino38732a0G2: Moderately differentiated (intermediate grade)CCCPrimaryleft kidney
IPIKID093.T2FemaleOtherNon Hispanic or Latino36653a0G3: Poorly differentiated (high grade)CCCPrimaryright kidney
IPIKID094.T1FemaleWhiteNon Hispanic or Latino25413b01G4: Undifferentiated (high grade)CCCPrimaryright kidney
IPILUNG081.T1MaleOtherNon Hispanic or Latino30552a0G3: Poorly differentiated (high grade)ADCPrimaryupper lobe of left lung
IPIMEL283.T1MaleWhiteNon Hispanic or Latino33714b2a1Not AvailableNot AvailablePrimaryright arm
IPIMEL321.T1MaleWhiteNon Hispanic or Latino28422b0XNot AvailableNot Available
IPIMEL343.T1MaleWhiteNon Hispanic or Latino28794b20Not AvailableNot AvailablePrimaryright great toe
IPISRC001.T1FemaleWhiteNon Hispanic or Latino25762bXNot AvailableSPrimarybuttock
IPISRC003.T1FemaleWhiteNon Hispanic or Latino2469Not AvailableNot AvailableNot AvailableNot AvailableNot AvailablePrimary
IPISRC004.T1FemaleOtherHispanic or Latino27841XNot AvailableSLocalRecurrenceleg
IPISRC009.T1FemaleAsianNon Hispanic or Latino18802bXG2: Moderately differentiated (intermediate grade)SPrimaryleft side of back
IPISRC012.T1FemaleAsianNon Hispanic or Latino27482aXG3: Poorly differentiated (high grade)SLocalRecurrenceleg
IPISRC013.T1MaleWhiteNon Hispanic or Latino22742bXG3: Poorly differentiated (high grade)OtherPrimaryleg
IPISRC014.T1MaleWhiteNon Hispanic or Latino35672bXG3: Poorly differentiated (high grade)SMetastasisarm