Archetype Feature Distributions
| Tcells | Myeloid | Stromal | Treg | CD4 Tcells | CD8 Tcells | Monocytes | Macrophages | cDC2 | cDC1 |
|---|---|---|---|---|---|---|---|---|---|
| Variable | Variable | High | High | Low | Very High | High | Variable | Low | Variable |
Potential Origin of this Archetype
Chronic inflamation and Tissue repair, Tissue resident CD8 T cells-Treg, Sustained by IFN and TGFB signalling
Archetype Tumor transcriptomic program
TGFb signalling, IFN signalling, Prostaglandin
Archetype Chemokines Expressed
CCL8 CCL11, CCL16, CCR3, CXCL1 CXCL5, CXCL6, CXCL8 CXCR2, CCL2, CCR2, CXCL9, CXCL11, CXCL12 CXCR3 CXCR4
Archetype Immune Transcriptomic Programs
Tissue resident T cells (Trem), High Exhaustion, Suppresive Tregs, Neutrophils
Immune Archetype Gene Signature
Table of Archetype Feature Scores
Table of Archetype feature flow Populations
Table of Archetype non feature flow Populations
Histology Abbreviations
ADC = Adenocarcinoma NOS PSC = Papillary Serous Cystadenocarcinoma C = Carcinoma NOS SCC = Squamous Cell Carcinoma NOS CCC = Clear Cell Carcinoma NOS EA = Endometriod Adenocarcinoma S = Sarcoma NOS TCC = Transitional Cell Carcinoma NOS
| Sample | Gender | Race | Ethnicity | BMI | Age | T Stage | N Stage | M Stage | Grade | Histology | Tumor type | Extraction Site |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IPIBLAD006.T1 | Male | Asian | Non Hispanic or Latino | 23 | 65 | 4a | 2 | G3: Poorly differentiated (high grade) | Not Available | Primary | Bladder | |
| IPIBLAD014.T1 | Male | White | Non Hispanic or Latino | 21 | 69 | 2b | 0 | G3: Poorly differentiated (high grade) | C | Primary | Bladder | |
| IPIBLAD019.T1 | Female | Not Reported | Not reported | 31 | 64 | 3a | 0 | G3: Poorly differentiated (high grade) | C | Primary | Bladder | |
| IPIBLAD028.T1 | Male | White | Non Hispanic or Latino | 28 | 76 | 3b | 0 | G3: Poorly differentiated (high grade) | TCC | Primary | Bladder | |
| IPIBLAD030.T1 | Male | White | Non Hispanic or Latino | 27 | 75 | 3a | 1 | G3: Poorly differentiated (high grade) | TCC | Regional Recurrence | Bladder | |
| IPIBLAD034.T1 | Male | Native Hawaiian or Pacific Islander | Non Hispanic or Latino | 29 | 76 | 4a | 2 | G3: Poorly differentiated (high grade) | TCC | Primary | Bladder | |
| IPICRC063.T1 | Male | White | Non Hispanic or Latino | 20.44 | 83 | 3 | 0 | 0 | G1: Well differentiated (low grade) | ADC | Primary | ascending colon |
| IPIGYN065.T1 | Female | Native Hawaiian or Pacific Islander | Non Hispanic or Latino | 55.94 | 59 | 1a | 0 | G1: Well differentiated (low grade) | EA | Primary | uterus | |
| IPIGYN085.T1 | Female | White | Hispanic or Latino | 21.74 | 54 | 2a | 0 | G3: Poorly differentiated (high grade) | PSC | Primary | ovary | |
| IPIGYN086.T1 | Female | Other | Not reported | 28 | 70 | 1c | X | X | G1: Well differentiated (low grade) | EA | Primary | ovary |
| IPIGYN088.T1 | Female | Asian | Non Hispanic or Latino | 26 | 57 | 4 | X | G3: Poorly differentiated (high grade) | C | Primary | fallopian tube | |
| IPIGYN105.T1 | Female | White | Non Hispanic or Latino | 22 | 62 | 1 | 0 | G3: Poorly differentiated (high grade) | EA | Primary | uterus | |
| IPIGYN110.T1 | Female | White | Non Hispanic or Latino | 23 | 80 | 3a | X | 1 | G3: Poorly differentiated (high grade) | EA | Primary | uterus |
| IPIHNSC062.T1 | Male | White | Non Hispanic or Latino | 26.27 | 53 | 3 | 2 | G3: Poorly differentiated (high grade) | SCC | Primary | oral Cavity | |
| IPIHNSC063.T1 | Female | White | Non Hispanic or Latino | 26.35 | 65 | 4a | 3 | 0 | G3: Poorly differentiated (high grade) | SCC | Primary | oral Cavity |
| IPIHNSC065.T1 | Male | White | Non Hispanic or Latino | 21.99 | 58 | 4a | 2 | Not Available | SCC | LocalRecurrence | tongue | |
| IPIHNSC070.T1 | Male | White | Non Hispanic or Latino | 26.97 | 73 | 2 | 0 | 0 | Not Available | SCC | Primary | oropharynx |
| IPIHNSC076.T1 | Male | White | Non Hispanic or Latino | 25.1 | 78 | X | 3 | 0 | Not Available | SCC | LocalRecurrence | cutaneous/subcutaneous mechanoreceptor cell |
| IPIHNSC077.T1 | Male | White | Non Hispanic or Latino | 18 | 70 | 4a | 0 | 0 | G3: Poorly differentiated (high grade) | SCC | LocalRecurrence | cutaneous/subcutaneous mechanoreceptor cell |
| IPIKID070.T1 | Male | White | Non Hispanic or Latino | 38 | 73 | 2a | 0 | G2: Moderately differentiated (intermediate grade) | CCC | Primary | left kidney | |
| IPIKID093.T2 | Female | Other | Non Hispanic or Latino | 36 | 65 | 3a | 0 | G3: Poorly differentiated (high grade) | CCC | Primary | right kidney | |
| IPIKID094.T1 | Female | White | Non Hispanic or Latino | 25 | 41 | 3b | 0 | 1 | G4: Undifferentiated (high grade) | CCC | Primary | right kidney |
| IPILUNG081.T1 | Male | Other | Non Hispanic or Latino | 30 | 55 | 2a | 0 | G3: Poorly differentiated (high grade) | ADC | Primary | upper lobe of left lung | |
| IPIMEL283.T1 | Male | White | Non Hispanic or Latino | 33 | 71 | 4b | 2a | 1 | Not Available | Not Available | Primary | right arm |
| IPIMEL321.T1 | Male | White | Non Hispanic or Latino | 28 | 42 | 2b | 0 | X | Not Available | Not Available | ||
| IPIMEL343.T1 | Male | White | Non Hispanic or Latino | 28 | 79 | 4b | 2 | 0 | Not Available | Not Available | Primary | right great toe |
| IPISRC001.T1 | Female | White | Non Hispanic or Latino | 25 | 76 | 2b | X | Not Available | S | Primary | buttock | |
| IPISRC003.T1 | Female | White | Non Hispanic or Latino | 24 | 69 | Not Available | Not Available | Not Available | Not Available | Not Available | Primary | |
| IPISRC004.T1 | Female | Other | Hispanic or Latino | 27 | 84 | 1 | X | Not Available | S | LocalRecurrence | leg | |
| IPISRC009.T1 | Female | Asian | Non Hispanic or Latino | 18 | 80 | 2b | X | G2: Moderately differentiated (intermediate grade) | S | Primary | left side of back | |
| IPISRC012.T1 | Female | Asian | Non Hispanic or Latino | 27 | 48 | 2a | X | G3: Poorly differentiated (high grade) | S | LocalRecurrence | leg | |
| IPISRC013.T1 | Male | White | Non Hispanic or Latino | 22 | 74 | 2b | X | G3: Poorly differentiated (high grade) | Other | Primary | leg | |
| IPISRC014.T1 | Male | White | Non Hispanic or Latino | 35 | 67 | 2b | X | G3: Poorly differentiated (high grade) | S | Metastasis | arm |