Immune Rich CD8 Macrophage Bias


Archetype Feature Distributions
Tcells  Myeloid  Stromal  Treg   CD4 Tcells   CD8 Tcells Monocytes  Macrophages  cDC2 cDC1
High High Low Variable Low High Variable Very High Low High

 


Potential Origin of this Archetype

Chronic inflamation in CD8 Tcells Macrophages sustained by IFN signaling
Chronic viral infection

Archetype Tumor transcriptomic program

IFN/CSF1 Signalling

Archetype Chemokines Expressed

CXCL9, CXCL11, CXCL12, CXCR3, CXCR4, XCL1, XCL2, XCR1

Archetype Immune Transcriptomic Programs

Type 1 Immunity (M1 and Th1), High in Nk cells, High Exhaustion, IFN/TNFa signalling, PD1-PDL1/2

 


 

Table of Archetype flow Populations      Immune Archetype Gene Signature      Table of Archetype Feature Scores

 


Histology Abbreviations

ADC = Adenocarcinoma NOS    PSC = Papillary  Serous Cystadenocarcinoma   PC = Papillary Carcinoma  SCC = Squamous Cell Carcinoma  CCC = Clear Cell Carcinoma NOS   EA = Endometriod Adenocarcinoma BS = Benign schwannoma

Table of Archetype Clinical Data
SampleGenderRaceEthnicityBMIAgeT StageN StageM StageGradeHistologyTumor typeExtraction Site
IPICRC058.T1FemaleWhiteNon His/Lat30.0488300G2 ADCLocal Recurrencecolon
IPICRC062.T1FemaleWhiteNon His/Lat30.4386300G1 ADCPrimarycolon
IPICRC089.T1MaleWhiteNon His/Lat21.4740NANANANABSPrimaryretroperitoneum
IPIGYN084.T1FemaleWhiteNon His/Lat26.99753aXG3PSCPrimaryabdominal wall
IPIGYN100.T1FemaleOtherHis/Lat41531a0G1EAPrimaryuterus
IPIKID027.T1MaleWhiteNon His/Lat29793aXG2CCC Primaryright kidney
IPIKID030.T1MaleOtherHis/Lat28.8593aXG3CCC Primaryright kidney
IPIKID043.T1MaleWhiteNon His/Lat25.9792a1G3PCPrimaryright kidney
IPIKID047.T1FemaleWhiteNon His/Lat22.4733aXGXOtherPrimaryright kidney
IPIKID048.T1FemaleAsianNon His/Lat27.55941G4CCC Primaryright kidney
IPIKID050.T1MaleWhiteNon His/Lat22.9894XG3PCPrimaryright kidney
IPIKID051.T1MaleWhiteNon His/Lat27.3633b0XG4CCC Primaryright kidney
IPIKID066.T1MaleWhiteNon His/Lat41682aXG3CCC Primaryright kidney
IPIKID074.T1MaleWhiteNon His/Lat28683aXG3CCC Primaryright kidney
IPIKID076.T1MaleWhiteNon His/Lat26683a0G4CCC Primaryright kidney
IPIKID078.T1MaleAsianNon His/Lat33633a0G4CCC Primaryright kidney
IPIKID079.T1MaleWhiteNon His/Lat32731aXG1PCPrimaryright kidney
IPIKID083.T1MaleAsianNon His/Lat25422a0G3CCC Primaryleft kidney
IPIKID084.T1FemaleWhiteNon His/Lat41492aXGXCCC Primarykidney
IPIKID086.T1MaleWhiteNon His/Lat34693a0G3CCC Primaryleft kidney
IPIKID091.T1MaleWhiteNon His/Lat28743aXG4CCC Primaryright kidney
IPIKID092.T1MaleOtherNon His/Lat35643aXG4CCC Primaryright kidney
IPIKID093.T1FemaleOtherNon His/Lat36653a0G3CCC Primaryright kidney
IPIKID099.T1MaleWhiteNon His/Lat25551aXG3CCC Primaryleft kidney
IPIKID100.T1FemaleAsianHis/Lat30793bXG2CCC Primaryright kidney
IPIKID102.T1MaleOtherHis/Lat29.8603b0G2CCC Primaryright kidney
IPILUNG006.T1FemaleAsianNon His/Lat24661a0G2 ADCPrimaryright lung
IPILUNG031.T1MaleAsianNon His/Lat22602b2GXSCCPrimaryright lung
IPIMELB002.T1FemaleOtherNot reported2076NANANANANAMetastasisPancreas